15 Responses

  1. Ruth
    Ruth August 25, 2014 at 6:37 am | | Reply

    He needs to do a Tube Tube video like the ALS.Any creative and unique ideas anyone?

    1. Gil DePaula
      Gil DePaula August 25, 2014 at 3:36 pm | | Reply

      Hi Ruth, thank you for the feedback. We have a video on YouTube that shows the system and its multiple configurations:

      You can also go to our website and read about what we are doing:

  2. Gil DePaula
    Gil DePaula August 25, 2014 at 3:34 pm | | Reply

    The glucose sensor partner company is iSense:

  3. Dan
    Dan August 25, 2014 at 3:54 pm | | Reply

    Here is my take: We will be talking about this ten years from now. A closed end loop system that sits outside of us that uses the same old insulin we have now is not going to pass through FDA approval. Once these things hit the real world, you can imagine how many various episodes of hypoglycemia and hyperglycemia are going to be reported.

    If there is any hope in the horizon, it is from something like nanotechnology such as SmartInsulin.

    This closed end loop is not smart.

    Nobody has put one through the ringer yet–a month on a person eating like people do without diabetes and various activity levels throughout the day.

    1. Gil DePaula
      Gil DePaula August 26, 2014 at 9:20 am | | Reply

      Hi Dan,
      Thank you for the feedback.
      Several of such trials have been done, for several days, in which people ate as much as they would like and exercised as much as they wanted, and virtually no cases of hyperglycemia nor hypoglycemia occurred. Search on the web, especially for the trials conducted by Dr. Russell and Dr. Damiano in Boston. At the ADA I met a woman who took part in one, and she told me that at first she couldn’t believe her glucose level was always near the target, and that after a few days sometimes she would even forget she had T1D. She said that she literally cried when the trial ended and she couldn’t wear it anymore. Of course, they don’t have a device like the Genesis yet, so they typically use 2 Tandem t-slim or OmniPod pumps and a Dexcom CGM, all controlled from a smartphone app.
      You can see what they accomplished in one of those trials here (on very active kids!):
      .. but there are many more… just google it. :)

      1. Dan
        Dan August 26, 2014 at 3:54 pm | | Reply

        A mean glucose of 133 is poor control in my book. That means, with standard deviation being factor in, these people are probably running around 100 to 180 at all times.

        I run, the majority of the day below 120 and have an A1C of 5.0.

        I will not risk my life having this computer run my diabetes for me with such poor results.

        They can define hyperglycemia any way they want. But the reality is, hyperglycemia is anything above 120. That is defined by your body.

        So, I stand in my prediction, that these devices will not control blood sugar in the normal range. 133 mean is far from normal.

        But, you do not care about running 6.0 and above A1c, go for it, it is your life.

        1. Doug
          Doug August 27, 2014 at 6:29 am |

          Dan, Cudos to meeting your goals however.

          Some would say an average BG under 100 (A1c of 5.0) for a type 1 has its own dangers. Immediate permanent dangers. And likely endangers others around you if you drive or operate any machinery. But as you said Go for it Its your life.

        2. Dan
          Dan August 27, 2014 at 5:45 pm |

          Who is this “some would say.” Whoever told you that does not what they are talking about. Are you kidding?

          A1c is an advanced glycation end product. Aging of all organs and organ system increases when glycation is accelerated. Any A1c above 6.0 is dangerous.

          Don’t believe anyone who states a glucose level between 70-100.

          Lab reference for normal blood glucose is 65-99 mg/dl. That is a fact. It cannot be ignored. Yes, 65 is normal.

        3. Dr. Dave
          Dr. Dave August 28, 2014 at 12:36 pm |

          Dan – you seem to have some issues. Glycemic control that tight (A1c of 5) is associated with poor outcomes in Type 1 diabetics. Furthermore, suggesting that Type 1 diabetics can or should try to achieve an A1c that low is dangerous and probably discouraging. As has been pointed out, these types of artificial pancreases have indeed been tried in the real world, and I’d say this is the most promising thing since the first successful synthesis of insulin. The introduction of glucagon makes the system awfully close to what a real pancreas does. The only missing link is the fact that the glucose sensed is that in the peripheral circulation rather than the portal circulation. Other systems (and hopefully this one as well) use machine learning and Bayesian prediiction to learn what works well for an individual patient. (Machine learning was the first thing I thought of when I heard of the artificial pancreas – if you can teach a computer to learn the physics behind kicking a soccer ball, you can teach a computer to learn how an individual responds to insulin and glucose.)
          It’s an exciting time for those of us who treat Type 1 diabetes, and undoubtedly much more exciting for those who have it.
          Dave S.

  4. Tim Brand
    Tim Brand August 25, 2014 at 6:47 pm | | Reply

    I really enjoyed meeting Gil last year at ADA and getting to know him. I’m very impressed with his vision and heart to help people withType 1 Diabetes. I wouldn’t mind seeing my girls wearing a Genesis. Good article Mike, keep up the great work Gil.


    1. Gil dePaula
      Gil dePaula August 26, 2014 at 8:39 am | | Reply

      Hi Tim,
      Thank you, and nice to hear from you. I hope your princesses are doing well.

  5. Bernard Farrell
    Bernard Farrell August 27, 2014 at 9:33 am | | Reply

    Very exciting to hear that work is moving forward. I’m especially happy that Pancreum will be publishing the data protocols, all device makes should be doing this.

    Best of luck with more funding.

  6. Alice
    Alice September 21, 2014 at 11:47 pm | | Reply

    I have been living with omnipod for the past 4 years and I love it. I have been type 1 for 10 y and usually running at hba1c around 7% on average which is comfortable. Great work Gil, exciting to see such development are being made and looking fw to hearing more! What about crowdfunding?
    Good luck

  7. Natalie Hodge
    Natalie Hodge October 5, 2014 at 7:18 am | | Reply

    I agree Gil! We had great success in our crowdfunding campaign with Medstartr last year. There are certainly other sites you could consider for this. You could even run your own crowdfunding campaign a la tile. Adding in a viral “challenge” like als concurrently would add to it! We will all be there to back you! Seriously now that the AP data is coming in and looking so promising, we must have the hardware to go with it! I am also wondering about rock health for you now that you are Bay Area? This may be an issue of market size, the t1 market being a relatively small market (as opposed to t2 matket). Let us know what we can do to help!

    Best, natalie

  8. Gil DePaula
    Gil DePaula November 12, 2014 at 7:43 pm | | Reply

    Crowd-funding has already been tried by us on Indiegogo. Unfortunately the problem is that nobody is willing to give money and potentially not be getting anything in return, or having to wait 3 years before getting it, i.e. please remember that it needs FDA approval before it can be shipped. We asked for $500 K to complete the prototype and got $2 K.

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