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9 Responses

  1. Sarah
    Sarah March 19, 2013 at 12:51 pm | | Reply

    This is awesome! I would see this as the next HUGE advancement in diabetes research. Sure a cure would be lovely- but this I can see actually working to improve my life (and make it easier) in the not way far away future!

  2. David
    David March 19, 2013 at 4:26 pm | | Reply

    I like the “predictive windows” looking far enough ahead that it might allow timely course corrections. Medtronic’s LGS is a good start, especially for pioneering the FDA regulatory pathway, but is too slow My basal rate is only 0.50 per hour, so if I’m dropping during sleep, a suspension of basal is going to take over an hour to help. I’d rather an alarm woke me up so glucose tabs can get me back on course in 20 minutes.

  3. Clarke
    Clarke March 19, 2013 at 7:57 pm | | Reply

    Promises and futures…. Animas is great at feeding the public with consistent propaganda. Trey have been saying they would have an integrated pump in the U.S. for 5 years now. Anyone seen it?

    Regarding this technology they speak of in this article. Old news once again. This has been studied by the leading company for well over 2 years now. If you are placing bets on who gets there first, better stick to the company whose yearly research and development budget is bigger than Animas total yearly sales. JDRF bet on the wrong horse. Wait, they should have at least bet on a horse who is actually in the race.

  4. Bennet
    Bennet March 21, 2013 at 9:07 am | | Reply

    I like the bit about how different cruise control systems are in the market. I think that different approaches to automation will fit different lifestyles. JDRF’s portfolio approach will lead to that different sizes for different folks.

    How was that for mixing metaphors? LOL

  5. Karl Fenn
    Karl Fenn March 23, 2013 at 12:25 pm | | Reply

    Of course it is interesting to see the speed of some technological developments, however many on the drawing board may never materialise, firstly, there has been some great advances in new drugs, The Mail last week, new insulin due to be released that lasts over 40 hours with a proven better control of blood sugars, we have seen the introduction of byetta, which superseded some of the old inslin regimes, this offers vastly superior control over blood sugar levels and long term stabilization of the condition in general, there are many new drugs comming on to the market at the moment, I understand the lastest release costs just £2.50 per day. In all probability within five years drugs will be so good the condition will be kept under control to near normal levels, following these developments I think a cure may emerge, however difficult to say how long this will take to acheive.

  6. Guilherme "Gil" de Paula
    Guilherme "Gil" de Paula March 24, 2013 at 11:30 am | | Reply

    Mike,
    That’s great news and technological advancement.

    On a different note, your statement “suspend insulin delivery ahead of time, to stop that hypo from happening” should probably be revisited. If your IOB is high (or the trend is sharply downwards), just stopping insulin delivery might not prevent the hypo, and you’d still need to wake/get up to take action.

  7. David Worthington
    David Worthington June 19, 2013 at 1:22 am | | Reply

    Model-Based control strategies like those described here can be implemented manually as well as in an automatic closed-loop device, and when done manually there is no need for FDA approval.

    You just need to start with a proper basal regimen, one that keeps normal BG from rising or falling all day long absent any food consumption at all. This is best done with a pump, but may be approximated with 3 tailored NPH injections per day. 24-hour insulins like Lantus and Levimer won’t work and should not be used because basal insulin need varies throughout the day.

    Then pre-meal bolus quantities may be calculated with the carb to insulin ratio, adjusted for BG with the insulin sensitivity, and corrected for IOB. The final trick is to measure BG two hours after eating, when most of the food has been absorbed but the bolus is still active. Then IOB may be used to predict BG for the next few hours, and if high, the appropriate supplement taken straight away, if normal, you’re OK, and if low, the carbs needed calculated. The prediction can even tell you how long you have to eat those carbs.

    When done right, BG at the next meal, or bedtime, will be close enough to normal you can even skip testing then should strip cost be an issue. And in the process bolus estimates for each meal are shown to be correct, or if not, how far off they were, and errors corrected immediately, minimizing high BG and virtually eliminating low BG, all while helping refine bolus estimates.

    How to do it is described in my paper http://synergistic.cc/Diabetes/ControllingBG.pdf and the implementation in http://synergistic.cc/Diabetes/PilotPoster.pdf

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