3 Responses

  1. Sarah Howard
    Sarah Howard May 4, 2012 at 5:59 am | | Reply

    Now this is interesting to me since environmental chemicals can affect the beta cells via ER stress (e.g., arsenic, BPA…refs below). These and other chemicals can affect the beta cells via other mechanisms as well, but I think these effects could be important for any type of diabetes.

    For example, see
    Lu TH, Su CC, Chen YW, et al. 2011. Arsenic induces pancreatic beta-cell apoptosis via the oxidative stress-regulated mitochondria-dependent and endoplasmic reticulum stress-triggered signaling pathways. Toxicol.Lett. 201(1):15-26.

    Makaji E, Raha S, Wade MG, Holloway AC. 2011. Effect of Environmental Contaminants on Beta Cell Function. Int.J.Toxicol.

  2. Russell Stamets
    Russell Stamets May 4, 2012 at 8:45 am | | Reply

    Wow! Thanks Mike and commenter Sarah. This all adds substantial weight to the understanding of diabetes as a spectrum disease and to the growing acceptance that toxins in our diet and environment may be to blame. Combined with the recent evidence of residual beta cell activity in longtime insulin users, support should grow for the assertion that fixing diet and stress levels show more promise than pharmaceuticals.

  3. Larry
    Larry May 6, 2012 at 8:53 am | | Reply

    I enjoyed watching this educational video. Finding links between Type 1 & 2 may lead to advances in the quest for a cure. We don’t often get a chance to see an interview with a doctor involved in research being funded by the JDRF.

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