62 Responses

  1. kdroberts
    kdroberts May 27, 2011 at 7:31 am | | Reply

    DPP-4 inhibitors and GLP-1 analogs do essentially the same thing. DPP-4 interferes with the messaging between the liver and pancreas which is done via GLP-1. It’s essentially a case of adding more GLP-1 to get the messages through or helping the GLP-1 you already have do it’s job better.

    DPP-4 inhibitors make me very nervous though since DPP-4 is used all over the body including the immune system and brain. One scary thing is the inhibitors lower the immune systems ability to stop certain cells turning into cancer cells. I guess they will either turn out to be fine or in 5-10 years there will be a slew of new cancer patients.

    I took Januvia for a while but after researching it more I personally wouldn’t take any of the DPP-4 inhibitors or GLP-1 analogs unless it was a last resort. The safety profile of them all is questionable and the results you actually get are usually very minimal, especially when you factor in the cost. Metformin and insulin would be my treatment of choice.

    1. EVG
      EVG January 20, 2013 at 11:19 am | | Reply

      My case is conplicated, to say the least. I have been on Tradjenta for almost a year. Good news/bad news. My legs were swelling up grotesquely to my congestive heart failure issues and reduced kidney function due to a partial nephrectomy of my right kidney. My new cardiologist switched me from Pradaxa back to Coumadin. My primary switched me from Metformin to Tradjenta. My kidney issues seemed to improve over the next 6 weeks as my urine flow gradually increased back to normal. The good news is the swelling in my legs has been reduced drastically. My gait is back to normal. The bad news is Tradjenta is expensive as hell. Being retired, I had to really, really adjust my monthly budget to accomodate the $.

  2. Barb
    Barb August 4, 2011 at 8:24 pm | | Reply

    But what about the weight gain from the insulin?

  3. Ezekial
    Ezekial October 19, 2011 at 9:49 am | | Reply

    I just started Tradjenta, one per day usually around 9:30 to 10:00 am with plenty of water and usually a breakfast of three eggs . I was on two 5/500 glyburide – metformin twice a day. Before taking the 5 mg Tradjenta I check my blood sugar with two meters the Freestyle and the One Touch Ultra 2. The Freestyle consistently shows lower readings by at least 10 to 15 points less than the Ultra2. I retest with both meters at the same time from the same blood droplet at least 4 times a day approximately 3 to 4 hours apart. My results after taking Tradjenta only without any other medicines or alternative supplements or NSAIDS (ibuprofen or naproxen sodium ) shows very little effect on bringing down my blood readings in the 190 to 300s. I have been on Tradjenta for two weeks and have seen no improvement in my readings anywhere near the readings from the glyburide – metformin that I was taking which were in the low 150 to 100 or less range when I ate a low carb mealsw and snacks. I can see little or no results positive or good from Tradjenta on my blood sugar readings. To me Tradjenta is useless.

  4. genesis
    genesis October 20, 2011 at 6:24 pm | | Reply

    I have just started Tradjenta coming off Levimir injections and 3 yrs. on the pump before that. ‘So far the Tradjenta is working well. My sugars are running 110-130 am fasting and then I’m around 115 before bed. This is also eating a healthy diet. I have also taken Byetta injections and it caused pancreatitis with kidney failure. After dialysis for 3 months my kidney function returned. So I would never take a drug in that class again. I know in my case, and I’ve been a type 2 for 20 years, that healthy eating is my only chance to keep a somewhat level

  5. Sheliah
    Sheliah October 25, 2011 at 11:05 am | | Reply

    Im just starting the Tradjenta today! Wish me luck! I was on Byetta for 1 & 1/2 yrs and got pancreatis. I have a enlarged liver and am concerned about what Ive read about this drug could cause triglyceridedemia. I have horrible side effects with metformin and sulfonylurea type drugs. This is my last resort before insulin. I wonder if the insulin would be the better choice!

  6. kim
    kim November 3, 2011 at 7:17 pm | | Reply

    I have been taking 1 glybruide and 1 metformin er in AM and 1 glybride/3 metformin at dinner. I started taking Tradjenta for 3 weeks and what a difference. yesterday went to Dr for follow up. Dr took me down to 1/2 glybride/1 Metformin AM and 1 glybride/2 metformin at dinner. My fasting numbers have gone from from 150-160, to 105-120 range. My post meal readings would swing way up and way down. It took about a week and they are getting more into ‘normal’ range. I have no side effects so far and I feel millions time better. Have to return for tests in 6 weeks to see how I am doing. If this doesnt work, I guess i have insulin next.

  7. Linda Mensching
    Linda Mensching November 20, 2011 at 5:56 pm | | Reply

    I started Tradjenta 2 weeks ago. My AM readings have gone from 169 to 107. I have not been this low in over a year. I have no side effects. My only concern is that no Medicare insurance will pay for it. I just checked with my insurance guy and he looked and said not one will pay for it. What am I suppose to do. I finally found one that works and i can’t afford to pay $250 a month for it. NOT FAIR

    1. Wayne
      Wayne December 16, 2011 at 8:20 am | | Reply

      The manufacturer has a low cost program of paying no more than $10 per month for two years.Talk to your doctor about getting the “savings card”.

      1. jimB
        jimB February 1, 2013 at 3:33 pm | | Reply

        The coupon is not valid for government insurance–i.e. Medicare D. Have your doctor or insurance co. check to see if another option in the class, like Januvia, is covered.

    2. Sally
      Sally September 30, 2012 at 10:05 am | | Reply


    3. James
      James October 12, 2014 at 5:12 pm | | Reply

      AARP pays, only cost 80.00 a month. According to next year it will be 40.00 a month.

  8. mskitny
    mskitny December 4, 2011 at 9:08 am | | Reply

    Just starting Tradjenta on 12/3/11, hoping for improvement in constant hunger.

  9. Robert Mendelson
    Robert Mendelson February 14, 2012 at 8:50 am | | Reply

    I started Tradjenta in December of 2011 as an additional drug to the metformin and glimiperide I was taking for years. My last A1C before December was 6.6! (Shows what discipline and exercise can do). My Endocrinologist is dead set on getting the A1C below 6. I don’t think that likely after 11 years of type II and being 61, even if I exercise the hour a day that I do and eat carefully (which I am pretty good about. I don’t think I am a good model as I never get side effects and eat a huge amount of protein and greens so I am not hungry ever. I will post what the A1C comes in at.

  10. Terri
    Terri February 29, 2012 at 11:27 am | | Reply

    Type 2 diabetic along with severe, chronic gastritis….I am never hungry so, while I eat healthful foods, many times I simply forget to eat so I go in to hypoglycemia. After 2 1/2 years on metformin which has worked well, my new endocrinologist informed me that metformin is very hard on the stomach so today he switched me Tradjenta. I wonder why my other doctors didn’t make the connection. Hopefully the new med will work as well as metformin and will allow my stomach to heal. Having diabetes and not being able to eat is a really bad combination. I won’t start taking the new med till tomorrow so will see how it goes.

  11. Janice Huffer
    Janice Huffer March 12, 2012 at 8:10 am | | Reply

    I am on day 2 of Tradjenta. I did two weeks of Actos and like all the injectables got a headache that makes a migraine look desirable. I cannot speak on feeling hungry-as I have not had a significant ‘hunger’ in 22 years. People or a timer remind me I need to eat. 10-15 years ago I developed ‘hypoglycymia’ and I knew it was time to eat when I would feel my life just drain out of my feet, get woozy and weak feeling. somewhere about 4 years ago my BG levels became elevated. Tried to control with diet–works if you actually eat! in Jan 2010 Endocrinologist put me on Janumet–started feeling very very tired. Jan 2011 switched to metformine–got very very sleepy. a sever asthma attack put me int he hospital/prednisone/BG is thru the roof–start insulin injections in the hospital. Numbers did not come down, I was comatose-I could hear, but there was no way I could respond to anything around me. Headaches–Dear Lord give me a migraine and take this headache away. My husband came into the hospital one night and said I was writhing in pain, holding my head and crying–I don’t remember that–the pain was too great!!! I was downing Relpax for the headache at almost every injection once I got home. When home health care released me–no insulin at all. I feel much more like me. My BG numbers keep going up. In light of all this, I am not convinced and do not accept that Type 2 is really the culprit. If it were–wouldn’t the meds work to some degree? They make me sicker than I care to be thank you very much.

    1. Robert Mendelson
      Robert Mendelson March 13, 2012 at 8:26 pm | | Reply

      Janice, that sounds horrible. Sounds to me like they are not finding a cause, but trying to treat symptoms. 3 questions/suggestions: How is your weight? Is your endocrinologist actually smart or just another person with a lot of drive that became well educated? Do you exercise? Best wishes

      1. Janice Huffer
        Janice Huffer March 15, 2012 at 3:36 am | | Reply

        Robert, in answer to your questions: 1. I weigh about 120 pounds more than I need to or want to, I weighed 40# more than I needed to 23 years ago when I got pregnant with my youngest. She weighed a whopping 12# at birth. She weighs all of 95# now. I am 5’1″ and 234#. Up until 8 months ago I exercised religiously, the weight goes no where; and after a severe asthma attack inthe endocrinologists office that they had absolutely no concern for–I never went back. And the Tradjenta is now causing the migraines as well. I agree-we need to find the cause-not treat the symptoms–Drs like the easy way thru–I cannot find yet anyone who will actually dig into what is causing the symptoms. It was after my last was born that my ability to get hungry or know when to eat disappeared. I also lost most of my hair and as the years have gone on my face takes on more round shape. If I can remember to eat regularly I can loose a few pounds–I have lost 13# since April 2011 most of it inthe last 7 months–since I lost my high stress job. I am an enigma. would love to find a doctor to take me on. Better yet–a miracle from God himself would suit me fine as well.

        1. Nan
          Nan March 19, 2012 at 9:59 am |

          Janice, have you been evaluated for Cushing’s Syndrome? Or had a pituitary MRI? Cushing’s may be a long shot since it is rare but it should be ruled out……

  12. Janice Huffer
    Janice Huffer March 19, 2012 at 10:19 am | | Reply

    Nan, about 20 years ago they ruled that out. Ruled out hypothyroid since my numbers were on the border but still WNL (within normal limits). If you recall Star Wars Princess Leah the hair do where she had two braids on either side of her head???…well I could do that with all my own hair up until 22 years ago. Now, my hair is still semi long (middle back) but so thin my scalp is very visible and easily sunburned. I pretty much have all the symptoms of hypothyroidism, without the numbers. I have absolutely no type 2 symptoms–only the numbers and I happen to be morbidly obese. it is easier to call it type 2 and keep throwing drugs at it. I am so frustrated. I quit going to doctors for years–until I was diagnosed with endometrial carcinoma in extreme early stage 1. I was told that was the one cancer most women never find out about until it is too late to do much for them. That was when the high BG numbers were discovered. My endo crinologist seemed disappointed that dental and eye exams NEVER showed signs of the type 2. usually eye exams show signs well before anything else points to it. Or so I am told. I am still looking for that special medical professional willing to look outside the box.

    1. Sally
      Sally October 3, 2012 at 5:41 am | | Reply

      Thyroid test are not always correct.Ask for a basal metabolism test .

      1. Janice Huffer
        Janice Huffer October 3, 2012 at 8:51 am | | Reply

        Sally, I will ask next time I go. However, I do have some good news to report. When I went to see the doc for a regular visit in August I had lost 12# in one month. I was horribly ill thru most of July. Now that my TMJ has progressed to the point of limiting the types of foods I can successfully eat, I started investigating VitaMix Blenders. i finally purchased one. i do a spot check on my glucose levels. Since i have started doing the vitamix, I have lost another 10#, glucose levels have dropped from 345-305 range to 245 area. I no longer have sever gut aches from eating. I do not want to sound like an advertisement for Vitamix, but for me and others like me–it has improved my quality of life. i haven’t had an A1C done since early August when it was in the 8-9 range…but, i believe it will be lower when we do do one again. I noticed that each time we changed drugs my glucose levels went up and stayed. It didn’t matter what I didn’t indulge in–they were NOT coming down. A few green smoothies and I am loosing weight, my spot checks are coming down, I don’t hurt when I eat or after wards, and the arthritis in my knees feels better. I can walk easier–not longer yet, just easier. I do not add any powders, vitiamin supplements or anything other than the whole foods to my blender (vita mix) and run. Knocking food down to the cellular level to absorb better and quicker, has been the key for this body. I will tell you a regular off the shelf blender cannot do what a vita mix does. tried it. The core of the pineapple has a host of healing properties that a regular blender cannot handle–vitamix can. Pharmacuetical companies pick up the cores of pineapples from plants that decore pineapple to use in medications. I get those benefits myself now. The other investment I made in me was a food saver to keep the fruits and vegies I use as fresh as possile until i use them. works wonders.

        1. Sally Bergmoser
          Sally Bergmoser October 3, 2012 at 10:50 am |

          I have a vita-mix .how do you make you’re drinks. Please just give me a few ingredients. Thanks. The reason you need a better thyroid test. my thyroid was not working at all the blood test didn’t catch it. So they did a basal metabolism test and found the problem.Thanks

        2. Janice Huffer
          Janice Huffer October 3, 2012 at 11:05 am |

          My favorite smoothie thus far is spinach smoothie.

          I use in the following order:
          white grape juice (no sugar added)
          frozen white grapes (two handfuls
          Half a seeded apple
          1 inch slice fresh pineapple-core included **
          half a banana-peeled
          1/2 cup or so plain greek yogurt (chobani)
          2 cups fresh spinach leaves-washed
          1/2 cup ice
          1 tsp honey or few strawberries with leaves or blueberries
          I will say-blueberries in this are delicious–just an ugly color.

          **buy fresh whole pineapple, slice into 1″ slices; remove the spiney outside (some will remain in slices you use–they blend in very well)

          this makes a full 48oz carafe and then some. I usually drink the whole thing in about 2 hours in the morning. I had my husband try this when he was home last weekend–he thought it was very good as well. You need the honey, or berries to offset the tang that greek yogurt has naturally. but I opted for the higher protien level of the greek yogurt.

  13. Joyce
    Joyce May 17, 2012 at 9:38 am | | Reply

    Type 2 diabetic, just starting Tradjenta 5mg daily today. I have been on Metformin since 1996, Dr. added Amaryl about 5 years ago. My BS numbers are pretty good during the day, but my fasting in the AM is getting higher and higher. So I will be taking the Tradjenta with my evening medications and hopefully it will work for me to bring my A1c and fasting back under control.

  14. Robert
    Robert May 17, 2012 at 8:52 pm | | Reply

    Well, i am six months into Tradjenta now and by A1C was at 6.5! It had gone under 7 for the first time in several years after 3 months on it and this has now repeated. I exercise on average 45 minutes a day (hard enought to sweat) and am 14% body fat at 6′ 1″, 203 pounds (35 inch waist). All of you, check with your doctor, and then do whatever aerobic exercise he tells you. It is the first effective thing entirely within our own control. All it takes is will power.

    1. Tom
      Tom August 2, 2012 at 12:21 pm | | Reply

      the exercise lowered the A1c, not the pill.

  15. Benjamin Bagaoisan
    Benjamin Bagaoisan May 22, 2012 at 12:33 pm | | Reply

    Prior to taking tradjenta 3 weeks ago I was taking Janumet 50/1000 twice a day and actos once a day. My BS reading in the AM is between 115 to 125, Because of the effect of Actos I told my Primary care Dr to replace the Actos. Went back to Glipizide twice a day. My DR advices me to stop Janumet and starting taking Tradjenta, by BS reading is getting higher and higher everyday for that 3 week period. my A1c also went up to 7.2 which it never did before the highest was at 6.8 and the low was 6.6. Looking back at my records why the DR stopped me from taking metformin is because of the EGR is fluctuating from 60 to <60 and the creatinin is high. I went to a nephrologist and he did not mention to me about having a problem with my kidney so I am getting confused. I need to se my DR again tomorrow if I can get back to Metformin and continue to take the tradjenta and glipizide.

  16. Michael Gallegos
    Michael Gallegos July 26, 2012 at 12:06 pm | | Reply

    I tried Tradjenta twice first time it felt like i had body fever , head ache and flu like symptoms . That was with injetitble insulin lantus & novolog. Second time Im on an insulin pump side effects were the same plus diarrhea lost 20# my legs were swelling and had sever piding edema. Also increase heart rate advised by my gastrointeroligest to stop taking for a few days and my kidneys stopped producing urine after 24 hours head ache. Stopped diarrhea stopped and started producing urine again.
    I also had reactions with ongliza and janumet .
    Im an IDDM diabetic so be careful when you take linagliptin .
    I feel 100% better after being off Tradjenta getting back to normal

  17. Angie
    Angie July 30, 2012 at 5:37 pm | | Reply

    I would like to know more from kdroberts and where they got their information on the immune system and the possiblity of cancer cells not being stopped from forming.

  18. susan marcero
    susan marcero August 4, 2012 at 8:09 am | | Reply

    good luck to you.
    I have had type two for 6 years. It’s been a real jumble. I was sensitive to Metformin also, but Actos worked well. Then I developed bladder problems. I went to the eurologist 15 times and said I think it’s the Actos. He kept giving me a blank stare saying “couldn’t be.” Then the truth came out in Europe and finally over here. I was changed to janumet and prandin. My A1C went up so I’m fighting to get it down. At least the Janumet does not bother my stomach. You could look into that. It seems like the combination does not cause as much irritation.

  19. Paulette Brooks
    Paulette Brooks October 2, 2012 at 10:21 pm | | Reply

    I am very frustrated! I have tried Victoza, byetta, Januvia, actos, and now I’m on tradjenta. Every one of them has made me sick to my stomach and the injections made me really sick and almost everyday I threw up. Now on tradjenta ( I’ve been on it for 2 1/2 weeks) I am sick to my stomach and get really bad headaches and I think its from the tradjenta. I am also on metformin and glimipiride. I can’t seem to get my blood sugar back to where it was. I actually was having trouble getting it to stay above 70 when I was on actos but then when the dr. took me off – I went up to the high 190′s and 200. Tradjenta is bringing it down to around 130. But I sure am tired of being sick.

    1. Sally
      Sally October 3, 2012 at 5:50 am | | Reply

      I’ve been on Trajenta for 7 days. I do have head aches hopefully they will go away, the slow release Metformin cause a lot of gas. My A1c was 8.3 when they put me on the Trajenta. blood sugars are coming down but I do have nausea . I do know I cheat too much on my diet. trying to control this but I do like bread and ice cream. Paula dean says she eats no sugar ice cream. need to find out what kind.anyway I’ll let you know in a few weeks how the trajentais doing .

  20. Sally Bergmoser
    Sally Bergmoser October 3, 2012 at 1:56 pm | | Reply

    Thank you.Janice

  21. Paulette Brooks
    Paulette Brooks October 3, 2012 at 6:56 pm | | Reply

    Thanks Sally, look forward to hearing more from you.

  22. Ray
    Ray November 2, 2012 at 7:12 am | | Reply

    I have type 2 and I take Metformin 1000mg 2x daily and glimepride 4mg in morning. I took actos and it made me gain weight and didn’t like the prospect of bladder cancer so I stopped taking it. My AIC went up over 7 even though I lost 15 pounds. Now the Doc gives me 5mg of Tradjenta and it’s expensive as hell and I’ve taken it for 2 days. I’ve take it before dinner with the 1000 mg of metformin. Morning readings have been 144 and 166. Am I taking tradjenta the wrong time of day. Please recommend the time of day to take it.

    1. Sally Bergmoser
      Sally Bergmoser November 2, 2012 at 8:01 am | | Reply

      My Dr. Says time of day doesn’t matter.but I ‘m having better sugars when I take it around 11:00 or 12:00 noon.

    2. Paulette
      Paulette November 2, 2012 at 10:57 am | | Reply

      Ray, I gained a lot of weight with the different meds my dr has put me on. I was really unhappy. Dr put me on tradjenta and I haven’t gained any more but have not lost any either. I go to the gym 3 times a week for an hour. I’m going to try it like Sally and take it around noon.

  23. Sally Bergmoser
    Sally Bergmoser November 2, 2012 at 7:58 am | | Reply

    Just had my one month check -up .on tragenta. Lost the 15 pounds gained from Levimir. Blood sugars is good range as long as I don ‘t cheat on diet.sometimes impossible . I like bread.this may sound crazy but I found that if I est burnt bread my sugars are OK? I don’t go back to the Dr for 3 months. Will check in again dr. Said tragenta can be taken anytime of the day. I usually take it around noon!

    1. Paulette
      Paulette November 2, 2012 at 10:47 am | | Reply

      Sally- I also went to dr on Oct 30th. My numbers were doing better until last week, so He wants me to go to my primary dr and check out somethings that might be causing that
      ( infection, etc) . Maybe I’ll try taking the tradjenta at a different time of day and see if it helps more. My #’s are usually high in the afternoon! The upset stomach faze has gone away but I’m still getting really bad headaches, so I have to check in with him in a month to see if I have to go off tradjenta and then I’ll have to go on insulin :( Hopefully not

      1. Sally Bergmoser
        Sally Bergmoser November 2, 2012 at 11:59 am | | Reply

        Hi, my DR. Said there are other drugs to try and he can raise the dosage of my other drugs. He is bound and determined to keep me off of insulin! Let me know how you do?

        1. Sally
          Sally November 3, 2012 at 5:26 am |

          OK! I take 2 500 mg. extended release Metformin in the morning and evening,at dinner. 1 Glimepiride 4 mg. in the morning .somewhere between 11;00 and 12 noon I take my tradjenta. the tradjenta didn’t work for 3 weeks it doing great now ! I hope this helps. I think the extended Metformin is good too !

  24. Bob
    Bob November 2, 2012 at 8:00 am | | Reply

    Ray, i take essentially the same thing. with me, it took about 4 or 5 days for tradjenta to start working. also, you may want to see if you are encountering the dawn phenomenon, which is a part of waking up. before you wake up, your liver starts pumping out glucose so you’ll have energy. in people without diabetes, the pancreas increases insulin production as a reaction to the increased glucose. for more on the dawn phenomenon look here:

  25. Wandra Dees
    Wandra Dees November 12, 2012 at 11:28 am | | Reply

    I started taking Tradjenta at least a year ago. I had been taking Metformin 500 mg daily and then increased to twice daily and then 1000 mg twice daily. After taking Tradjenta once daily along with Metformin 1000 mg twice daily, my fasting blood sugar dropped to 105 – 120, which was much better than with the Metformin alone. Now my fasting blood sugar has increased to 120 – 135. My biggest concern is that my mom just passed away with pancreatic cancer and she was also a Type II diabetic. What bothers me most is the possible effect of Tradjenta on my pancreas and the threat of pancreatic cancer for me.

  26. Sally Bergmoser
    Sally Bergmoser November 12, 2012 at 7:09 pm | | Reply

    I don’t see my dr, until Jan but I will ask him about the chance of getting cancer when I see him I will let you know what he says,? I’am having a lot of acid reflux. I think it’s from the meteformin? Anybody else have this problem ?

  27. Tammy
    Tammy December 6, 2012 at 3:36 am | | Reply

    Have a question.. diagnosed with type 2 diabetes in november, doc put me on insulin for about 6 days as sugars were extremely high.. 22.0 around there.. but after I had a headache one day sugar levels dropped lower.. and with diet stay around 5.0-7.7 but the endocrinoligist wants me to start trajenta now.. and afraid that my levels are within normal level as controlled by my change of diet and loss of weight that terrified I will drop hypoglycemic if I start medications now… any thoughts … thanks

  28. Sally Bergmoser
    Sally Bergmoser December 6, 2012 at 10:20 am | | Reply

    I have had very few low sugars on Tradgenta .iwas on insulin too made me gain weight ! Dr. David that since I’m a type ll I should not be on insulin.that’s why he put me on the Tradgenta along with meteformin slow release and onr 4mg. Glipride in the morning. Than 2 meteformin at dinner. So far my sugar is good except for when I cheat which I know is too often. But to answer your question low sugars are rare? Good luck!

  29. Teri
    Teri January 9, 2013 at 6:24 pm | | Reply

    I just started taking Tradjenta today. I took it about 8:00 pm because I am having problems with my morning sugar levels in the the mid 200′s. Any suggestion on when I should be taking it? My doctor said whenever I wanted to was fine.

  30. Bob
    Bob January 9, 2013 at 7:55 pm | | Reply

    Teri, take it right before you go to bed would be my suggestion. It seems that you have a real “dawn effect” or dawn phenomenon in your blood sugar. Check out these websites — and

    This is something many doctors don’t really focus on.

  31. Sally Bergmoser
    Sally Bergmoser January 10, 2013 at 8:41 am | | Reply

    I take mine whenever I remember it. I took my A1C after 2 months and it dropped from 8.3 to far so good! Experiment at different times to take it !i think it works differently on everybody.

  32. Sherri
    Sherri January 20, 2013 at 9:36 pm | | Reply

    I started taking this drug 6 months ago and it never controlled my sugar. My fasting was 157 on average with it. I started putting on weight shortly after starting it and it increased monthly. I just went to my Dr. and they found I have developed an irregular heart beat since starting the drug. I am now off the drug and back on Byetta which is the drug that worked the best for me from the start. I had wanted to get away from the injectable medication so I tried Tradjenta… BIG mistake! I hope my heart issues goes away soon.

  33. marwa mansour
    marwa mansour January 21, 2013 at 2:23 am | | Reply

    IAM apharmacist and i want to know what is the difference between tradjenta and any other medication of the same group forexample januvia or onglyza tell me plz what is tradjenta previlage over these medications i mentioned before

  34. Paulette
    Paulette January 21, 2013 at 11:36 am | | Reply

    Marwa, I don’t know anything about onglyza but Januvia did absolutely nothing for me. I am happy to say that I have been on Tradjenta for a few months now and my numbers are perfect and I’ve lost 11 of the 13 I gained on Actos!. So as far as I’m concerned I love it. At first I had upset stomach which lasted about two weeks and I had headaches which lasted about a month but now I am doing just great. I am also on metformin 500 mg twice a day and Glimipiride 4mg twice a day. But I have a feeling when I see my dr in Feb, he’s going to take me off the glimipiride! Hope this helped a little.

  35. Ellen MacKinzie
    Ellen MacKinzie March 17, 2013 at 3:00 am | | Reply

    I’ve had Type II for 14yrs and been on all of the meds: Metformin, Januvia, Janumet, Onglyza, Actos and now Tradjenta and Glyburide. Took Metformin forever started with 500mg then went to 1000mg twice a day which caused Neuropathy of the stomach. Was terrible ill (throwing up everything and nausea). Only good thing I lost 20lbs, but now being on Glyburide twice a day and Tradjenta I’ve gain it back and have very high readings in the A.M. Normally I took it at night with my other medicine with hopes of getting better morning reading, but it didnt work. I’ve tried taking it at noon, and in the morning but it didnt seem to matter as my readings are always the same. I’m not a breakfast person and my BG really spikes to over 200 in the morning, and sometimes it crashes to 62. My kidneys are starting to fail and I think its from the Tradjenta even though it states it work via your gut acids not your kidneys. I too are concerned that it forces your panceas to produce insulin. As far as weight it seems know matter how much I exercise I cant loose a pound. My doctor claims this medicine doesnt put weight on you and I do get headache form time to time (not real bad), and I have to force myself to get moving and do things. I’ve been told I’m Syndrome X. I dont think there is a good medicine out their or an answer.

    1. Robert Mendelson
      Robert Mendelson April 23, 2013 at 4:10 pm | | Reply

      Hi all, Well i have had type 2 since i was 50, for about 12 years now. Tradjenta has helped with the A1C quite a bit. Last two times 6.8 and 6.4. The key is to really work on what you eat. I know its what my mother told me, eat your vegetables (and i really hate them, but it works). eat spinach, kale, broccolli, carrots, brussel sprouts and red, yellow and green peppers, preferably fresh. Also, talk with a smart doctor about the benefits of chromium and alpha lipoic acid. Or read the blood sugar solution, ignore the hype and oversell in it and just follow the diet and supplements after talking with your doctor.
      Oh yes, drive right past McDonalds, Wendy’s, Kentucky Fried Chicken and all that other stuff. The only real way to eat healthily is at home. I wish you all good luck but don’t leave your life to the medication, take control of your food intake and you will have success.

      1. Dee Browne
        Dee Browne May 20, 2014 at 2:07 pm | | Reply

        I have type 2 diabetes. Was on insulin but with diet, losing 90 lbs., and 45 – 60 min. walking or other aerobics each day, I had to come off insulin (120 units per day). That was 25 years ago. I exercise every day of my life and most of the time eat a well balanced diet. It took me nine months to succeed but thank God, with His help If I could do it – anyone can!

  36. Sally Bergmoser
    Sally Bergmoser March 17, 2013 at 6:37 am | | Reply

    TRADJENTA may affect the way other medicines work, and other medicines may affect how TRADJENTA works.
    I do not take tradjenta with any other meds. It is the last pill I take at night.

  37. Yvonne Torres
    Yvonne Torres April 2, 2013 at 7:26 pm | | Reply

    I have been taking trajenta for 4 months now . The last time my
    A1C was a 8.6. I check my sugar everyday and it was always high
    Which would frustrate me. Well I just went back for my 3 mo. Checkup
    And I was told my A1c was 6.8 I guess the trajenta is working after all. I’ve
    Been a diabetic for 7 years I take 1000 mg of metformin in the morning and 1000 mg at bedtime. Then I take 4mg of amaryl in the morning and at bedtime
    Trajenta 5mg in the morning. I was on actos before from the lowest to the highest dose. Started gaining a lot of weight then I felt so bloated all the time to where I couldn’t sleep “I” took myself off of that actos . I told thr dr I know how my body feels you don’t . He then put me on januvia it didn’t do nothing for me at all, after a few months he put me on junamet the strongest dose twice a day. I took this for 4 months . Omg it was hell I felt worse than a pregnant woman always throwing up. I never knew how I was going to feel that day. I think my sugars were in control I just couldn’t bear the sickness anymore after 4 months. For the longest I was on metformin and amarly. Then my A1c was
    7.0 three months later 7.1 three months later 7.7 three months later then 8.6 then after adding the trajenta it went down to 6.8. I feel so sleepy at times and I’ve been hungry more . I feel like I’m gaining a little. So then I try not to eat as much. I eat whatever I want in moderation.

  38. Jack Walters
    Jack Walters June 6, 2013 at 6:11 am | | Reply

    I have been on Tradjenta for the lat 2.5 months I don’t have a blood test for my AC-1 until July, my last AI-1 reading was 7.4. For the last week, my numbers have been high in the mornings and also the evenings. I don’t eat after 8:00 PM. I have been a type 2 since I turned 50 years old. I’m 66 years old. I take a 1000 mg. Metformin twice a day along with Glimepiride 2-mg. I appreciate the feedback each person was willing to share on their numbers and the Tradjenta medication.

  39. Sally Bergmoser
    Sally Bergmoser June 6, 2013 at 7:01 am | | Reply

    I take the Tradgenta when I know I’ll be eating fods with high carbs. If, you’re waking up with high sugars take it at night. It is expensive ask your doctor for the coupon on the samples he gets

  40. marsha
    marsha June 11, 2013 at 9:17 pm | | Reply

    try getting in touch with the manufacturer of tradjenta they have a patient assistance program you can obtain med free for 1 year

  41. rb
    rb August 14, 2013 at 4:32 am | | Reply

    Has anyone had any peripheral pain while taking Tradjenta? The symptoms I am experiencing is pain in the hands, feet and mid-back. I was diagnosed with diabetic neuropathy, but am wondering if it is because of the Tradjenta. The pain has been so bad at times that I can’t walk without assistance and even had the doctor get me a handicapped placard because of my inability to walk.

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