Comments on: The Truth About Afresa Inhalable Insulin: A Chat with Al Mann

By: Reen

Reen — Mon, 08 Mar 2010 17:27:14 +0000

Begley- I completely agree with you.
I’m 34 yrs old, was diagnosed at 7. I have been living with type 1 for many years. I was luck enough to be on Exubera for 2 years. I just ran out off supply in January and have gone back on 5 injections a day. It stinks. I contact Mannkind regularly to see if FDA approval has come yet. Exunera worked fantastically for me and I expect the same from Afresa, once it finally hits the market. For those of you who don’t take injections or 5 a day, you have no right to provid einput. At least Afresa give us an option..to live a normal life without stabbing ourselves so many times!

By: stage 3 lung cancer

stage 3 lung cancer — Thu, 25 Feb 2010 15:51:25 +0000

stage 3 lung cancer…

Your topic ” The Truth About Afresa Inhalable Insulin: A Chat with Al … was interesting when I found it on Thursday searching for stage 3 lung cancer in Google…

By: Begley

Begley — Tue, 19 Jan 2010 12:12:14 +0000

what i dont understand is why diabetics themselves are skeptical of something that could possibly reduce the amount of injections they have to do per day.as a young woman and a diabetic i personally would prefer not to have bruises and lumps all over my body and not to have a factor directly affecting my weight. also the prospect of an inhaler makes the process of taking insulin more bearable for those who do not take it as they cannot put up with the inconvenience of having injections every time they just want to have the simple pleasure of having something to eat.i also find that diabetics get little sympathy when expressing this feeling.i get frequently ill which affects my education and would prefer to have an option other than injections that is available quicker than ten years,when something else will be available but bodies will have been damaged both externally and internally beyond repair. i beleive that people who arent diabetic should stop trying to influence decisions as they do not go through what is in fact a very seriousness illness. Iam sure alot of younger diabetics would agree.

By: Scott K. Johnson

Scott K. Johnson — Mon, 30 Nov 2009 01:39:45 +0000

I totally don’t understand how I (as a type 1) would not have to count carbs anymore. How is that possible?

By: Felix Kasza

Felix Kasza — Tue, 24 Nov 2009 18:59:49 +0000

One major aspect that I have not seen mentioned is that type-2 diabetics usually have a functioning glucagon system, affording them fairly solid protection from hypoglycaemia. Type-1s? Not so much, after a few years of D. So if you are a type 1 diabetic, you may want to take all of this “no carb-counting with Afresa” stuff with a grain of salt.

By: steveg

steveg — Mon, 23 Nov 2009 23:58:41 +0000

I have been using Exubera since it came out and I bought as much as I could before it was pulled from the market and am still using it now. I have been T1 for 38 years and my control has never been better. I use lantus as a basal every morning (12 units). And use exubera in varying doses at varying times when I eat meals. I have had my lungs checked twice with no change from when I started. I am extremely fit, lean, ride mountain bikes 4X a week. So I will be extremely pleased when this new drug makes it to market (before I use my last Exubera!). Just because people are used to doing 4 shorts a day does not make it good. If my blood sugar is a little high, I just take one puff of 1mg and it comes back down. My life is 100% better with Exubera. Don’t be resistant to trying the new stuff, you may be very pleasantly surprised. Any change is tough, and I was very wary about going to Exubera but now I can’t live comfortably without it.

By: smitten

smitten — Fri, 20 Nov 2009 18:45:44 +0000

Study results

http://care.diabetesjournals.org/content/30/9/2307.full.pdf

CONCLUSIONS— In this study, inhalation
of TI led to markedly improved
postprandial glycemic control compared
with subcutaneous RHI, whereas total serum
insulin exposure was almost identical
with each treatment. TI had a more
rapid absorption and achieved higher peak
insulin levels than subcutaneous RHI.
These unique pharmacokinetic properties
of TI may provide better postprandial
glucose control compared with RHI
achieved with a similar insulin exposure.
Occurrences of hypoglycemia and
hyperglycemia were similar with TI and
subcutaneous RHI treatment, with no severe
occurrences. The incidence of treatment-
emergent mild-to-moderate
adverse events was comparable between
treatments. Three subjects reported a single
event of cough during TI treatment.
The results of our clinical experimental
study support the utility of TI as an
alternative to subcutaneous RHI to cover
postprandial insulin requirements. TI
markedly improved postprandial blood
glucose control in subjects with type 2
diabetes. Use of prandial TI, as part of an
intensified insulin therapy, might provide
better glycemic control than subcutaneous
RHI. Long-term studies are under
way to confirm the promising efficacy,
safety, and tolerability profile of TI seen in
our study.

By: David J. Webb

David J. Webb — Fri, 20 Nov 2009 18:33:44 +0000

I am curious. What would happen if instead of lungs, they used a spray to introduce it under the tongue? This would go to the blood stream as well.
I can see a great usage for this one. Most Type IIs have put quite a strain on the pancreas over the years. Perhaps this could be used to allow the pancreas time to recover.
There is a reason for the insulin resistance in type IIs. It is a protective thing to keep the insulin from over whelming the cells. Does this drug lower that protection? If not fine, if so, then we might be trading one problem for another. My original reaction to some drugs suggests heart problems might become an issue. That is why I am extremely cautious about using insulin even though it would bring my levels down dramatically. Treating the symptom instead of the basic cause is something missed by both doctors and type IIs and has been for years. I see a lot of potential benefits from this treatment. I also see a lot of potential problems. How does it affect Leptin levels for instance. I am not a doctor or wish to become one. I do my homework. Most doctors do not have that type of time. I would be interested in following this research in future articles.

By: Dunstan

Dunstan — Fri, 20 Nov 2009 17:17:20 +0000

Carol the data is overwhelming. Go to this link and listen to the presentation dates 5/12/09. Dr. Peter Richardson gives a presentation summarizing the data that has been submitted to the FDA.

http://www.news.mannkindcorp.com/phoenix.zhtml?c=147953&p=irol-presentations

By: Carol

Carol — Fri, 20 Nov 2009 15:12:44 +0000

Thanks to those of you who provided clarification with regard to potential use of this product by T1’s. Especially thanks to Matthew and Pat Godin, the T1 study participants who had vastly different experiences. That’s the problem at this point for me…. the only “evidence” presented here with regards to T1’s is testimonial rather than with study results. Can anyone point us to study results for T1’s using Afresa? I could care less about the stock price and PR for this, but show me (with real evidence) that it will make life better for us without compromising other aspects of our health, and you will have my attention.