12 Responses

  1. tmana
    tmana July 10, 2008 at 7:13 am | | Reply

    One concern I’m not hearing addressed is the autoimmune component of autoimmune diabetes… isn’t there a high probability that the same path that kills the beta cells will destroy the k cells and/or the insulin they produce?

  2. Scott
    Scott July 10, 2008 at 8:04 am | | Reply

    Colonic irrigation or hydrotherapy is very popular in Hollywood these days! While this is interesting, there is some scientific evidence which suggests potential problems, too. The first, as tmana aptly noted, is the issue of ongoing autoimmunity … something that INGAP and beta cell regeneration treatments are now exploring how best to address in type 1s. The other is the suitability of the location … we know that with islet transplantation, the host site in the liver is believed to be one reason that sustained insulin independence is seldom observed — there’s a very good reason the beta cells have a home in the Islets of Langerhans! Then there is the little issue of diabetes complications like gastroparesis as well as autoimmune-mediated celiac disease which could adversely impact the idea of K cell therapies. While these ideas are hopeful, take it from those of us who have many more decades of hearing how close a cure is … don’t hold your breath waiting!

  3. jeremiah
    jeremiah July 10, 2008 at 9:03 am | | Reply

    working hard to improve treatment yes trying to find a cure not so much it comes down to simple economics.. and just a bit of a sort of trivia question what was the last disease ever cured and what year or decade?

  4. Melissa
    Melissa July 10, 2008 at 9:43 am | | Reply

    Last I remeber is wiping out polio with a vaccine, not a cure, and even that wasn’t completely successful. Nope, don’t hold your breath for a cure, they’ve been saying the cure is right around the corner since 1923.

  5. jeremiah
    jeremiah July 10, 2008 at 10:08 am | | Reply

    thats also around the same time polio got its vaccine makes you wonder why no progress has been made since then??

  6. Beth
    Beth July 10, 2008 at 2:28 pm | | Reply

    Regarding tmana’s comment, I think even though K-cells and beta cells are both insulin-producing they probably are physically different. My biology is fuzzy, but I believe the antibody grabs on to specific folds on a protein. K-cells might be different enough to escape.

    Anybody catch the article about a gastric surgery reducing Type 2?

    Basically, if they perform a bypass around the upper small intestine Type 2 diabetes goes into remission. I know the two diseases are totally different, but when considered next to the K-cell therapy, it sounds like the GI tract may play a bigger role in glucose regulation than anyone realized — these guys may be on to something.

  7. Titos
    Titos July 10, 2008 at 4:22 pm | | Reply

    Regarding diseases that have been cured or can be treated:

    - 60 years ago virtually any bacterial disease or infection could have killed you, then they discovered antibiotics (incl. typhus, cholera, syphilis, leprocy, meningitis, encephalitis …..) as well vaccines
    - 50 years ago you would probably have died from minor heart disease (including kids born with congenital heart defects, so called blue babies), then in the 50s and 60s they discovered heart-lung machines and how to operate on living hearts
    - All types of major surgery and specially organ transplants were virtually impossible 40-50 years ago, today some are even routine and there are people alive today using artificial hearts
    - 20 years ago you probably would have gone blind from glaucoma, today while it cannot be cured progress can be arrested and blindness avoided with over 90% success rate
    - 85 years ago you would have died very quickly from Type-1 diabetes, today in Europe life expectancy for people with diabetes diagnised before age 15 is around 10 years less than average (ie around 55 years with diabetes). For people who got T1-D in the 40s and 50s, life expectancy was 20-25 years. Latest statistics that I saw in Germany, amputations from diabetes are down almost 50% in the last 20 years, as well as diabetes related blindness.
    - Life expectancy for people with many types of cancer has increased significantly over the past 10-15 years as has life expectancy for people with HIV-Aids (which today is almost “only” a chronic disease – 10-15 years ago it was a death sentence)

    So its slow going and frustrating, but hang in there !!!

  8. Fernando
    Fernando July 10, 2008 at 6:58 pm | | Reply

    Hi Amy,

    First of all, Awesome blog.
    Great post.
    Isn’t amazing what the human mind is capable of doing?
    One thing.
    Every day of my diabetic life, I am glad that there are pharmaceutical companies out there rolling in dough. Thanks to them and their profit motive I am still alive. Sometimes we ignore the fact that big pharma only makes profits by saving and improving our lives. I hope big pharma gets even bigger and makes even more money. I wouldn’t like for any medicine lab to be working on the next glucose monitor in some dinky, wet and dirty basement somewhere in a third world country due to a lack of funds, would you? We need to remind ourselves that pharmaceutical companies are in the business of making medicines to treat diseases, they are not in the business of finding cures. I am so thankful they exist and that they are successful.

  9. Julie Woods
    Julie Woods October 19, 2008 at 11:58 am | | Reply

    You must have hope.

  10. insulin strips
    insulin strips January 3, 2009 at 8:33 pm | | Reply

    What possible reason should testing strips require a prescription from your doctor?

    If I buy a testing machine from my neighborhood pharmacy, it includes some free strips. No prescription required!

    Strips cost about $1 each. Based on my experience as a manager of a retail store selling computers, I would estimate that the pharmacy is making $0.30 to $0.50 for each strip they sell.

    If you could buy strips from ebay, I bet they would be $1.00 each.

    Hum, just had a thought…. Maybe I can buy them mail order from a Canadian Pharmacy.

    Great blog. I will add it to my bookmarks.

  11. insulin strips
    insulin strips January 3, 2009 at 9:03 pm | | Reply

    I mis-wrote a comment in my earlier post. I should have said something like “I bet test strips would be a lot less than $1.00 each if they were sold on Ebay.

    While checking out the price of diabetic tests striips, I looked at 1 pharmacy in Canada. They were charging $1.09 per strip.

    Humph, no bargain at that Canadian on-line pharmacy. I will check some more of the pharmacies and give my results.

    Any diabetic out there know of a way to buy test strips for less than $1.00 each? I am 63 and soon may not be covered by any insurance plan.

    By the way:

    Bell pepper cut into four peices – insides seeds removed. No cut up an avocado into four pieces and lay them inside the cut up bell pepper. Nice evening snack. If you use green bell pepper, I think there is minimal sugar. Red bell peppers seem to be sweeter, so I would think they have more sugar.

    Luck to everybody.

  12. Diabetes Type
    Diabetes Type May 7, 2009 at 6:14 pm | | Reply

    Would be amazing if they could come up with a cure, but do you know how much that would cost us! I don’t know if that is reasonable, is it? It is nice to think about but I feel like it will not be in my life time, I hope my kids will be able to live without diabetes.

    I want sweets right now!

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