4 Responses

  1. ADA SF Conference Preview: Big Trial Results

    [...] Chen, R., Hussain, K., Al-Ali, M., Dattani, M. T., Hindmarsh, P., Jones, P. M., Marsh, P. wrote an interesting post today onHere’s a quick excerptThe American Diabetes Association’s huge annual conference hits the city of San Francisco this Friday, June 6. Of course I plan to be there, running around like a madwoman trying to catch all the interesting briefings, … [...]

  2. Fenton
    Fenton June 2, 2008 at 1:04 pm | | Reply

    Wow, all type 2 stuff. I’m a little tired of all the research, all the money, and all the media attention being on the Type 2s – cause that’s where the numbers are and that’s where the money is. I’m sorry, but there’s already a cure for type 2 – it’s called not being fat. Now, can we cure my autoimmune disease so I don’t have to wear this device on my hip?

  3. tmana
    tmana June 2, 2008 at 5:33 pm | | Reply

    With all due respects to Fenton, T2 is not necessarily a condition of obesity, though obesity can cause a T2 syndrome to hit clinical diagnosis state, and while weight loss can often lessen the intensity of T2, it does not cure T2. (I’m waiting for the pundits to realize that what’s currently called “T2″ is a spectrum of disorders, some of which are comorbid conditions.)

    The current safety issues with T2 meds — like some of the issues Jenny (Janet Ruhl of suspects of insulin analogues — are one of the issues behind the push to develop new oral medications (another, of course, is that proprietary chemical configurations fall out of patent protection much sooner than creative works under the copyright laws).

    As far as T1, I should certainly like to see you be able to “get rid of that device on your hip”. One would hope that eventually novel genetic engineering should be able to address that; unfortunately, the path is frought with long development times, socialpolitical issues, and moralistic misdirection (“if we can mess with diabetes genes, why shouldn’t we mess will all genes and create what is effectively a society of clones?”). Meanwhile, it would seem that if the Artificial Pancreas Project could get the expert-systems correct, the next step would be a completely implantable device… which would still require periodically refilling the internal reservoir.
    On the third hand… has anyone experimented with using immunosuppresants on people with autoimmune disorders (and does the efficacy thereof depend on the degree to which the disorder has affected the body’s systems)?

  4. Lauren
    Lauren June 3, 2008 at 7:55 pm | | Reply

    If the “cure” for type 1 involves immunosuppressants (esp T cell modulators) the cure will be worse then the disease. I’ll take T1 over cyclosporine or infliximab.

    I also hate the word “cure,” which I hear most often from the parents of type 1s rather than type 1s themselves. In medicine, at least in my experience, there are very few magic bullets. There are very effective measures for preventing disease (e.g. vaccines) and there are treatments of varying efficacy, but cures don’t abound. Personally, I think anyone diagnosed with type 1 will be dependent on exogenous insulin for the rest of their life. I would like research to focus on preventing complications and lengthening the lifespan of diabetics rather than chasing a pipe dream.

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