Comments on: Stem Cell Cure for Diabetic Mice, Suicide Genes, etc. http://www.diabetesmine.com/2008/02/stem-cell-cure.html A gold mine of straight talk and encouragement for people living with diabetes Sun, 12 Feb 2012 21:05:41 +0000 hourly 1 http://wordpress.org/?v= By: LUIS http://www.diabetesmine.com/2008/02/stem-cell-cure.html/comment-page-1#comment-60533 LUIS Wed, 03 Sep 2008 01:28:45 +0000 http://diabetesmine.dreamhosters.com/2008/02/27/stem-cell-cure-for-diabetic-mice-suicide-genes-etc/#comment-60533 We have being trying with humans in Mexico (Juarez Chihuahua)8 months ago ,we have implanted 190 cells in 190 patients , 57 of them are diabetics [54 type 2 and 3 type 1] but the cells we use are from their own body they are called Adult stem cells.Obtained from the pacient bone marrow with out any possible side efect , so far the results have being good on 80% of the patients and the other 20% have responded slowly. One big problem is the follow up of the treatment ,because the tretament requires at least 3 months to see results plus the following therapy . We are doing know also the harvest of the stem cells that way the patients can see results sooner . Like I said before we barely started 8 months ago and so far it's been good . We are getting more patients that have diabetes type 2 every month , I will keep you all posted with the results. Thank you Luis M. We have being trying with humans in Mexico (Juarez Chihuahua)8 months ago ,we have implanted 190 cells in 190 patients , 57 of them are diabetics [54 type 2 and 3 type 1] but the cells we use are from their own body they are called Adult stem cells.Obtained from the pacient bone marrow with out any possible side efect , so far the results have being good on 80% of the patients and the other 20% have responded slowly.

One big problem is the follow up of the treatment ,because the tretament requires at least 3 months to see results plus the following therapy .

We are doing know also the harvest of the stem cells that way the patients can see results sooner . Like I said before we barely started 8 months ago and so far it’s been good . We are getting more patients that have diabetes type 2 every month , I will keep you all posted with the results.

Thank you Luis M.

]]> By: Remi http://www.diabetesmine.com/2008/02/stem-cell-cure.html/comment-page-1#comment-46452 Remi Sat, 19 Jul 2008 07:32:36 +0000 http://diabetesmine.dreamhosters.com/2008/02/27/stem-cell-cure-for-diabetic-mice-suicide-genes-etc/#comment-46452 The cells were then injected into a mouse model of muscular dystrophy. The injected cells contributed up to 94% of muscle fibers, providing therapeutic value by restoring muscle structure and function in the mice. The added adult stem cells also formed a reservoir of new satellite cells (repair stem cells) in the muscle, and could participate in further repair if there was subsequent injury to the muscle. The cells were then injected into a mouse model of muscular dystrophy. The injected cells contributed up to 94% of muscle fibers, providing therapeutic value by restoring muscle structure and function in the mice. The added adult stem cells also formed a reservoir of new satellite cells (repair stem cells) in the muscle, and could participate in further repair if there was subsequent injury to the muscle.

]]> By: MoHo http://www.diabetesmine.com/2008/02/stem-cell-cure.html/comment-page-1#comment-40198 MoHo Sun, 02 Mar 2008 04:24:24 +0000 http://diabetesmine.dreamhosters.com/2008/02/27/stem-cell-cure-for-diabetic-mice-suicide-genes-etc/#comment-40198 I wonder if the coated pig islets have a recurrent "low" problem like the stem cells. Amy, can you get the scoop? Please... I wonder if the coated pig islets have a recurrent “low” problem like the stem cells. Amy, can you get the scoop? Please…

]]> By: Merrill http://www.diabetesmine.com/2008/02/stem-cell-cure.html/comment-page-1#comment-40197 Merrill Sat, 01 Mar 2008 16:48:30 +0000 http://diabetesmine.dreamhosters.com/2008/02/27/stem-cell-cure-for-diabetic-mice-suicide-genes-etc/#comment-40197 Thanks Doug, That is so very exciting. Do you know of a way to become involved in the Denver tests? We live about 5 hours away in SE Idaho. Merrill Thanks Doug,

That is so very exciting. Do you know of a way to become involved in the Denver tests? We live about 5 hours away in SE Idaho.

Merrill

]]> By: Doug http://www.diabetesmine.com/2008/02/stem-cell-cure.html/comment-page-1#comment-40196 Doug Fri, 29 Feb 2008 05:02:21 +0000 http://diabetesmine.dreamhosters.com/2008/02/27/stem-cell-cure-for-diabetic-mice-suicide-genes-etc/#comment-40196 Hi Katie. You had a question as to whether scientists have proven that the alginate capsule protects the pig islet cells inside from the T1 patients immune system. Apparently the capsule is porous allowing the free exchange of glucose, insulin and all essential nutrients between the host and cells. However, the pores in the alginate capsules are small enough to exclude cells, keeping the pig islet cells in and the host immune cells out. Therefore, the islet cells are effectively hidden and the patient doesn't need to have immunosuppresive drugs. They have injected these into patients in Russia and there have been no adverse events after nearly 9 months (immunoreactions etc). Apparently a clinical trial is planned for the Barbara Davis Centre for Childhood Diabetes in Denver, CO, starting 2009. In the press release i just read dated Feb 27, Prof Eisenbarth from the Barbara Davis Centre is quoted as saying "The lack of adverse effects and the encouraging early clinical results from LCTs first Diabacell(R) trial have prompted us to do a trial here in Denver." Sounds like he has reasonable confidence that the alginate capsules work. Hi Katie. You had a question as to whether scientists have proven that the alginate capsule protects the pig islet cells inside from the T1 patients immune system. Apparently the capsule is porous allowing the free exchange of glucose, insulin and all essential nutrients between the host and cells. However, the pores in the alginate capsules are small enough to exclude cells, keeping the pig islet cells in and the host immune cells out. Therefore, the islet cells are effectively hidden and the patient doesn’t need to have immunosuppresive drugs. They have injected these into patients in Russia and there have been no adverse events after nearly 9 months (immunoreactions etc).
Apparently a clinical trial is planned for the Barbara Davis Centre for Childhood Diabetes in Denver, CO, starting 2009. In the press release i just read dated Feb 27, Prof Eisenbarth from the Barbara Davis Centre is quoted as saying “The lack of adverse effects and the encouraging early clinical results from LCTs first Diabacell(R) trial have prompted us to do a trial here in Denver.” Sounds like he has reasonable confidence that the alginate capsules work.

]]> By: MoHo http://www.diabetesmine.com/2008/02/stem-cell-cure.html/comment-page-1#comment-40195 MoHo Thu, 28 Feb 2008 03:24:14 +0000 http://diabetesmine.dreamhosters.com/2008/02/27/stem-cell-cure-for-diabetic-mice-suicide-genes-etc/#comment-40195 I'm with Rob here, what about Microislet (in San Diego, CA) and LCT?! From what I have read they have been very successful with treating humans in Russia and NZ, specifically LCT. Microislets' founder is a T1, too. I’m with Rob here, what about Microislet (in San Diego, CA) and LCT?! From what I have read they have been very successful with treating humans in Russia and NZ, specifically LCT. Microislets’ founder is a T1, too.

]]> By: Merrill http://www.diabetesmine.com/2008/02/stem-cell-cure.html/comment-page-1#comment-40194 Merrill Thu, 28 Feb 2008 02:50:44 +0000 http://diabetesmine.dreamhosters.com/2008/02/27/stem-cell-cure-for-diabetic-mice-suicide-genes-etc/#comment-40194 So now in another article I see a drug cocktail when mixed with an anti-inflammatory enzyme will actually kick start the pancreas again into working. After time, enough islet cells will produce insulin in sufficient quantities again. Sounds like the magic bullet indeed. My question posed to my email to novacell was this. Scientists are now able to produce embryo like stem cells coaxed from skin cells. If the patients own skin cells were used to produce embryonic stem cells and then those cells are used to produce islet beta cells, would there be an autoimmune problem? As I see it there are two immunity problems, the first is the autoimmune problem caused by certain enzymes in the pancreas that cause the white blood cells to attack the islet cells. Apparently as the direct result of a particular gene in the patients body. The other is the immunity one has to cells introduced from other sources such as cadavers or pigs. My question was in regards to the outside sources and the body's response to this. I'm uncertain about the ability to hide the new islet cells with the use of seaweed or algae and still have them function properly. While algae sounds good, has it actually been proven in tests? If not, has novacell even looked at this potential option of using skin cells as a direct source. Additionally, if lab generated islet cells from skin cells in sufficient quantity can be produced, they could possibly take the place of the current external sources and thus decreasing or leaving out entirely the use of anti rejection medicine. I do like to see scientists attacking the issue from all directions. Its getting close don't you think? Tell me what you think. So now in another article I see a drug cocktail when mixed with an anti-inflammatory enzyme will actually kick start the pancreas again into working. After time, enough islet cells will produce insulin in sufficient quantities again. Sounds like the magic bullet indeed.

My question posed to my email to novacell was this. Scientists are now able to produce embryo like stem cells coaxed from skin cells. If the patients own skin cells were used to produce embryonic stem cells and then those cells are used to produce islet beta cells, would there be an autoimmune problem? As I see it there are two immunity problems, the first is the autoimmune problem caused by certain enzymes in the pancreas that cause the white blood cells to attack the islet cells. Apparently as the direct result of a particular gene in the patients body. The other is the immunity one has to cells introduced from other sources such as cadavers or pigs. My question was in regards to the outside sources and the body’s response to this. I’m uncertain about the ability to hide the new islet cells with the use of seaweed or algae and still have them function properly. While algae sounds good, has it actually been proven in tests? If not, has novacell even looked at this potential option of using skin cells as a direct source. Additionally, if lab generated islet cells from skin cells in sufficient quantity can be produced, they could possibly take the place of the current external sources and thus decreasing or leaving out entirely the use of anti rejection medicine. I do like to see scientists attacking the issue from all directions. Its getting close don’t you think? Tell me what you think.

]]> By: Katie http://www.diabetesmine.com/2008/02/stem-cell-cure.html/comment-page-1#comment-40193 Katie Wed, 27 Feb 2008 15:53:48 +0000 http://diabetesmine.dreamhosters.com/2008/02/27/stem-cell-cure-for-diabetic-mice-suicide-genes-etc/#comment-40193 I will never be able to understand why stem cell transplants get all the press-- isn't it true that no one has been able to rid T1's of the autoimmune tendency that kills islets, regardless of whether the islets are from your own body, from stem cells, from human donors, etc.? Only Dr. Denise Faustman has made some progress with turning off this autoimmune attack, but only with mice. Why do stem cells get all the attention? Because no one wants to think about the fact that the immune system will destroy those new cells at some point and the "cured" person will have T1 all over again? I don't get it. I will never be able to understand why stem cell transplants get all the press– isn’t it true that no one has been able to rid T1′s of the autoimmune tendency that kills islets, regardless of whether the islets are from your own body, from stem cells, from human donors, etc.? Only Dr. Denise Faustman has made some progress with turning off this autoimmune attack, but only with mice. Why do stem cells get all the attention? Because no one wants to think about the fact that the immune system will destroy those new cells at some point and the “cured” person will have T1 all over again? I don’t get it.

]]> By: gina http://www.diabetesmine.com/2008/02/stem-cell-cure.html/comment-page-1#comment-40192 gina Wed, 27 Feb 2008 15:52:54 +0000 http://diabetesmine.dreamhosters.com/2008/02/27/stem-cell-cure-for-diabetic-mice-suicide-genes-etc/#comment-40192 We are having Dr. Cherie Stabler from the Diabetes research institute chat on March 19 so if anyone has questions they can ask her! We are having Dr. Cherie Stabler from the Diabetes research institute chat on March 19 so if anyone has questions they can ask her!

]]> By: Rob http://www.diabetesmine.com/2008/02/stem-cell-cure.html/comment-page-1#comment-40191 Rob Wed, 27 Feb 2008 15:36:23 +0000 http://diabetesmine.dreamhosters.com/2008/02/27/stem-cell-cure-for-diabetic-mice-suicide-genes-etc/#comment-40191 Ok - great, they might be able to treat a few patients but 15% of them are going to get cancer. Why is this newsworthy? Meanwhile, LCT in New Zealand is in Phase I/II testing on ACTUAL HUMAN PATIENTS with islet replacement therapy using encapsulated porcine islets. As far as I can tell from what they're publishing, the patients are performing better than expected and are all off of insulin. This is without immunosuppression mind you. <a target="_blank" href="http://biz.yahoo.com/iw/080212/0361151.html" rel="nofollow">http://biz.yahoo.com/iw/080212/0361151.html</a> Why is Novocell the one getting the press? This is just baffling. Ok – great, they might be able to treat a few patients but 15% of them are going to get cancer. Why is this newsworthy?

Meanwhile, LCT in New Zealand is in Phase I/II testing on ACTUAL HUMAN PATIENTS with islet replacement therapy using encapsulated porcine islets. As far as I can tell from what they’re publishing, the patients are performing better than expected and are all off of insulin. This is without immunosuppression mind you.

http://biz.yahoo.com/iw/080212/0361151.html

Why is Novocell the one getting the press? This is just baffling.

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