The theory is solid and simple: Put your ideas of sensitivites to dosages and diet aside intially – diet is always going to be important factor. The liver will regulate the insulin in your bloodstream provided it has enough of it from the pancreas and barring that as long it has suplimented insulin by another form such as oral delivery. The holy grail has always been delivery of insulin into liver as opposed to directly into bloodstream. Life as a diebetic is difficult – in the main because you’re injecting insuling directly into your bloodstream which in itself opens up a large range of problems and which has created a multi-billion dolllar ancillary industry.

What Oramed is doing/trying to do has not been done before, but at the very least they have a great pedigree, being Hadassah in Jerusalem. They are in trial and the FDA makes them test healthy volunteers before diabetics. Test on healthy people showed that there was delivery of insulin into liver via oral capsule. That part of it shouldnt be any different on diabetics – a diabetic’s digestive system is going to do the same thing.
Whether its Oramed who does this or someone else, its the right strategy and hopefully diabetics will have a very positive life change as a result.

To my mind not even close to a Cure – better Control but still a Rigamaroll*

To the poster who asked how effective an insulin can be that you can give to healthy people without making them crash: This is how insulin analogs are initially tested, too. The method is to either keep the dosage small and let the body’s glucagon system handle the matter; or to feed volunteers, give them insulin, and measure (via C-peptide) how much less insulin the body produces on its own to balance the carbs; or to hook volunteers up to an euglycaemic clamp — a double infusion of glucose and insulin, with a feedback loop to keep BG stable — and to watch how much glucose the system needs to infuse to keep BGs stable against the insulin being tested.

Cheers,
Felix.

products like these I think are really just marketed to that population of Type 2 folks who are being threatened by their dr’s with the *gasp* possibility that they will have to take insulin. I hate that dr’s use it as a threat. But many of those folks want something easier and possibly a once a day pill would be good for them.

If the pill has to clear the stomach and reach intestines before gel dissolves and absorption uptake occurs, doesn’t that imply incredibly unpredictable time-lags before any medicinal benefit happens and how can you possibly match your food intake to this bizzare insulin delivery pattern????

mcityrk