Insulin in a Pill?

Why don’t we have insulin in
a pill? Because the stomach digests it
before it gets into the bloodstream. Pharmaceutical companies have long been working to overcome this
barrier, but until now, the little bit that made it into the bloodstream was
insufficient to make a difference. Until
now… maybe, hopefully! Clinical trial
results on a new insulin pill called Intesulin
have just been released showing that it is 60-70% as effective as injected
insulin. It lowered glucose levels
comparably, and kept those levels steady for patients throughout the day.

At the American Diabetes
Association conference
this weekend, Coremed, Inc. announced new clinicalTake_a_pill_1

trial
results on Intesulin in two “proof of principle” studies with Type 2 diabetics.
In both studies, Intesulin was compared to a placebo (“blank” pill) also to
Aspart analog (short-acting injected) insulin. Patients showed a significant decline
in C-peptide and rise in insulin levels, meaning their insulin resistance was
being suppressed. Intesulin has a first insulin peak at 30 minutes, compared to
Aspart, which peaks at 60 minutes. Overall, patients showed an average decline
of 30% in their daily average glucose levels. There wasn’t a single incidence
of gastrointestinal irritations, adverse effects or hypoglycemia (low blood
sugar), the company reports.

Last year, Coremed, Inc.
also signed a joint venture partnership agreement with China-based Wanbang and
Fosun pharmas to develop its Alveair (TM) inhalable insulin,
which is also looking quite promising as an eventual competitor to Pfizer’s
Exubera.

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8 Responses

  1. Diabesidad
    Diabesidad June 15, 2006 at 11:25 am | | Reply

    Por que NO hay insulina oral?: Intensulin

    Amy Tenderich en Diabetes Mine hace esta pregunta y nos informa de una inovacion. El problema radica en que al entrar en el proceso digestivo a nivel del estomago la insulina se digiere antes de entrar al torrente sanguineo. Las compañias farmaceutica…

  2. David Edelman
    David Edelman June 15, 2006 at 1:08 pm | | Reply

    Amy, you are full of good news this week!

  3. Diabetes Daily
    Diabetes Daily June 17, 2006 at 3:29 pm | | Reply

    Insulin in a Pill and Other Great News

    Amy Tendrich of Diabetes Mine posted three inspiring stories this week. So you can smile, too, here they are: Insulin in a Pill? “Why don’t we have insulin in a pill? Because the stomach digests it before it gets into the bloodstream. Pharmaceutical co…

  4. Jo's Cafe
    Jo's Cafe June 19, 2006 at 3:14 am | | Reply

    Diabetes in the News

  5. Jo's Cafe
    Jo's Cafe June 19, 2006 at 3:14 am | | Reply

    Diabetes in the News

  6. Jo's Cafe
    Jo's Cafe June 19, 2006 at 3:14 am | | Reply

    Diabetes in the News

  7. Dr.Pravin Ahir
    Dr.Pravin Ahir July 6, 2006 at 11:24 pm | | Reply

    want to know the details ba/be trial on Oral Insulin therapy, also want to the compny and Investigator contact No. for the same

  8. Insulin in a Pill and Other Great News

    [...] Insulin in a Pill? “Why don’t we have insulin in a pill? Because the stomach digests it before it gets into the bloodstream. Pharmaceutical companies have long been working to overcome this barrier, but until now, the little bit that made it into the bloodstream was insufficient to make a difference. Until now… maybe, hopefully! Clinical trial results on a new insulin pill called Intesulin have just been released showing that it is 60-70% as effective as injected insulin. It lowered glucose levels comparably, and kept those levels steady for patients throughout the day.” [...]

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